Human Cancer Biology Aberrant L1 Cell Adhesion Molecule Affects Tumor Behavior and Chemosensitivity in Anaplastic Thyroid Carcinoma

نویسندگان

  • Koon Soon Kim
  • Jeong-Ki Min
  • Zhe Long Liang
  • Kyungmin Lee
  • Jung Uee Lee
  • Kwang-Hee Bae
  • Min Hee Lee
  • Seong Eun Lee
  • Min Jeong Ryu
  • Soung Jung Kim
  • Yong Kyoung Kim
  • Min Jeong Choi
  • Young Suk Jo
  • Jin-Man Kim
  • Minho Shong
چکیده

Purpose: Anaplastic thyroid carcinoma (ATC) is one of the most invasive human cancers and has a poor prognosis. Molecular targets of ATC that determine its highly aggressive nature remain unidentified. This study investigated L1 cell adhesion molecule (L1CAM) expression and its role in tumor-

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Aberrant l1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinoma.

PURPOSE Anaplastic thyroid carcinoma (ATC) is one of the most invasive human cancers and has a poor prognosis. Molecular targets of ATC that determine its highly aggressive nature remain unidentified. This study investigated L1 cell adhesion molecule (L1CAM) expression and its role in tumorigenesis of ATCs. EXPERIMENTAL DESIGN Expression of L1CAM in thyroid cancer was evaluated by immunohisto...

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تاریخ انتشار 2012